Browsing Biomedical and Molecular Sciences, Department of by Title
Now showing items 241-260 of 429
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Lipid signalling modulates neuroendocrine cell excitability and cation channel function
Ion channel function and modulation determine the strength and duration of periods of enhanced neuronal activity and excitability that control and shape behaviour. The bag cell neurons of the hermaphroditic sea snail, ... -
Lipopolysaccharide-Mediated Regulation of IL-17 Receptor Levels in Human Monocytes
(2011-06-22)IL-17 promotes inflammation through the recruitment of monocytes and induction of various chemokines and inflammatory cytokines. Monocytes respond to IL-17 through the heteromeric IL-17 receptor (IL-17R) composed of ... -
The Long-Term Cardiovascular and Behavioural Consequences of Maternal Iron Restriction During Gestation in Rat Offspring
(2009-01-26)Maternal and fetal stressors during development can permanently alter various physiological functions and impact long-term health. These alterations are said to be programmed because they persist long after the original ... -
Long-term heme synthesis inhibition: vascular implications
(2008-06-30)Heme is essential for numerous enzymes involved in the regulation of vascular tone; it is an integral component of nitric oxide synthase and soluble guanylyl cyclase, and is the substrate for heme oxygenase, enzymes critical ... -
Low-Dose Carbon Monoxide Exposure in Pregnancy; a Potential Therapeutic for Pre-Eclampsia
(2014-05-01)Preeclampsia (PE) is a maternal disorder of pregnancy, characterized by late-onset hypertension and proteinuria. It affects roughly 5-7% of all pregnancies worldwide and is a leading cause of maternal and fetal/neonatal ... -
Lymphocyte Contributions to Local and Systemic Cardiovascular Regulation in Mouse Pregnancy
(2010-09-02)Healthy term pregnancy requires precisely timed coordination of multiple systems, including reproductive, neuroendocrine, immune and cardiovascular. Dynamic maternal alterations occur systemically as well as locally within ... -
Mandibular Torus : A Synthesis of New and Previously Reported Data and a Discusssion of its Cause
(2016-07-14)Using original data on 1,5000 mandibles, but mainly previously published data, I present a overview of the distribution characteristics of mandibular torus and a hypothesis concerning its cause. Pedigree studies have ... -
Markers of Cardiovascular Dysfunction After Pregnancies Complicated by Pre-Eclampsia
(2015-04-27)Pre-eclampsia (PE) is a hypertensive disorder of pregnancy characterized by maternal systemic endothelial dysfunction. While the clinical manifestations resolve soon after delivery, a large body of epidemiological evidence ... -
Maternal Cardiovascular Adaptations in Rodent Models of Pregnancy Complications
(2015-04-28)Pregnancy induces a myriad of time-dependent changes to the maternal cardiovascular (CV) system and correct orchestration of these adaptations is vital for pregnancy success and future health of both mother and offspring. ... -
Mechanical stretch increases Kv1.5 current through interaction between the S1-S2 linker and N-terminus of the channel
The voltage-gated potassium channel Kv1.5 mediates the ultra-rapid delayed rectifier current (IKur) in the heart, important for human atrial repolarization. In physiological conditions cardiomyocytes continuously undergo ... -
A Mechanism of Regulation of Hypoxia-Inducible Factor 1 Alpha by Nitric Oxide
(2014-09-12)Low tissue oxygen levels, known as hypoxia, characterize many solid cancers. Both clinical and experimental studies have demonstrated that intratumoral hypoxia is associated with malignant progression defined by increased ... -
Mechanisms inhibiting sympathetic neurotransmitter release during gastrointestinal inflammation
(2008-09-04)Inflammatory bowel disease (IBD) alters neuronal regulation of the gastrointestinal (GI) tract. The superior mesenteric ganglia (SMG) contain sympathetic neurons that modulate GI functions such, as motility and blood flow. ... -
Mechanisms of Amiodarone and Desethylamiodarone Cytotoxicity in Human Lung Cells
(2009-11-26)Amiodarone (AM) is a potent antidysrhythmic agent which can cause potentially life-threatening pulmonary fibrosis, and N-desethylamiodarone (DEA) is a metabolite of AM that may contribute to the toxicity of AM in vivo. ... -
Mechanisms of Heme-Oxygenase-1 Cytoprotection for Gene and Cell Based Therapies against Cardiovascular Disease
(2009-04-23)Establishing the cellular and molecular basis for cardiovascular disease and the application of tools to manipulate the cardiovascular system genetically provide potential for new forms of treatment against cardiovascular ... -
Menadione as a Novel Approach to Increasing Carbon Monoxide Production in Pregnancy: Establishing a Possible Therapeutic Role in Pre-eclampsia
Despite its negative connotation as a toxic gas, carbon monoxide (CO) is involved in anti-inflammatory, cytoprotective and vasodilatory processes, suggesting a possible therapeutic role in many disease states. Endogenous ... -
Messenger RNA Expression of the ABCA3 Transporter and Vascular Nitrite Distribution in Rat Aorta After Treatment with Glyceryl Trinitrate
(2009-06-24)ABCA3, a 150 kDa protein belonging to the ATP-Binding Cassette (ABC) transporter superfamily, has been shown to play a role in surfactant production in humans. However, in bacteria, ABC transporters are known to mediate ... -
The mexCD-oprJ multidrug efflux operon in Pseudomonas aeruginosa: regulation by the NfxB-like novel regulator PA4596 and envelope stress
(2009-08-20)Expression of the mexCD-oprJ multidrug efflux operon is enhanced by the presence of membrane damaging agents [e.g., the biocide chlorhexidine (Chx)] or mutations in the nfxB gene encoding a repressor of efflux gene expression, ... -
Moderate Ethanol Consumption by the Pregnant Guinea Pig Increases Ethanol Preference in Offspring
(2009-06-24)Ethanol teratogenicity involving the developing brain is the leading preventable cause of mental deficiency in the Western world. Chronic prenatal ethanol exposure (CPEE) may be a risk factor for ethanol abuse and altered ... -
Modification of Nucleotide Excision Repair Activity by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and Sulforaphane
The studies described in this thesis investigated the relationship between the DNA repair pathway nucleotide excision repair (NER, which is critical for protecting against carcinogenesis), and two exogenous chemicals, the ... -
Modulating the gut microbiota with a synthetic stool “MET-1”: protective effects in animal models of antibiotic associated colitis
(2013-10-02)Antibiotics disrupt the normal balance of the gut microbiota and may subsequently reduce colonization resistance, allowing pathogenic bacteria to colonize and cause disease. By re-introducing normal microbiota from a donor, ...