Browsing Biomedical and Molecular Sciences, Department of by Title
Now showing items 356-375 of 415
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Salmonella Enterica serovar Typhimurium Infection in Mouse Pregnancy
Salmonella are Gram-negative, intracellular food-borne pathogens that cause pregnancy complications. In pregnant mice, Salmonella enterica serovar Typhimurium (S.Tm) infection results in placental bacterial replication, ... -
SAXS and X-ray Crystallography Studies of the Cellulosome from Clostridium thermocellum
(2010-09-14)Cellulosomes are the most efficient plant cell wall degradation machines discovered to date. All cellulosomal components contain protein modules connected by linkers of varying lengths, which are predicted to be flexible. ... -
Scorpion Toxin BeKm-1 Prevents Low K+ Induced Internalization of Cell-Surface hERG Channels
(2015-08-07)The human ether-à-go-go related gene (hERG) encoded the pore forming subunit of a K+ channel that conducts an important current for the repolarization of the cardiac action potential. Dysfunction of the hERG channel leads ... -
Secretion and Antifibrinolytic Function of TAFI from Human Platelets
(2009-09-26)Thrombin activatable fibrinolysis inhibitor (TAFI) is a human plasma-derived zymogen that is activated through proteolytic cleavage by thrombin, thrombin in complex with thrombomodulin, or plasmin. Active TAFI attenuates ... -
Sensory-Mechanical Responses to High-Dose Methacholine Bronchoprovocation: The Modulating Effects of Deep Inspirations
Rationale: The physiologic variables distinguishing classic asthma (CA), cough variant asthma (CVA), and methacholine (MCh)-induced cough with normal airway sensitivity (COUGH) are incompletely understood. Defining the ... -
Sequence and Structure Based Protein Folding Studies With Implications
(2011-09-30)As the expression of the genetic blueprint, proteins are at the heart of all biological systems. The ever increasing set of available protein structures has taught us that diversity is the hallmark of their architecture, ... -
The Serum-‐ and Glucocorticoid-‐Inducible Kinase SGK1 and SGK3 Regulate hERG Channel Expression via Ubiquitin Ligase Nedd4-‐2 and GTPase Rab11
(2013-08-14)The rapidly activating delayed rectifier potassium channel (IKr) encoded by the human ether-a-go-go related gene (hERG) is a crucial component of cardiac repolarization of the action potential. ... -
Sex, estrogen and the role of cardiac vasoactive gene systems in the modulation of cardiac hypertrophy in ANP gene-disrupted mice
(2013-08-28)Sex dimorphism in the prevalence, onset, development and progression of cardiovascular disease (CVD) is well recognized. Sex-specific differences in adaptation to cardiac pathological progressions such as cardiac hypertrophy ... -
SFO Neurons are Glucose Responsive
(2009-09-29)Glucose is the primary metabolic signal reflecting the current energy state of the body. Glucose influences the excitability of neurons in the area postrema (AP), a circumventricular organ (CVO), prompting my interest in ... -
SHP2/PTPN11 Protein-Tyrosine Phosphatase Promotes Mast Cell Homeostasis and Systemic Mastocytosis
(2013-06-25)KIT receptor (CD117) is a receptor tyrosine kinase crucial for homeostasis of mast cells (MCs) in tissues and recruitment to sites of inflammation and tumors in response to its ligand Stem cell factor (SCF). Gain of function ... -
Sialylation of cell surface glycoproteins facilitates formation of 3D multicellular prostate cancer spheroids
Prostate cancer spheroid based three-dimensional culture models (referred to as prostaspheres) have provided insight into prostate cancer biology by highlighting the importance of cell–cell interactions and the extracellular ... -
Single Nucleotide Polymorphism of B-Type Natriuretic Peptide and Carotid Ultrasound Imaging as Biomarkers to Determine the Severity of Atherosclerosis
Cardiovascular disease (CVD) has been the number one cause of death in the world for several decades and will continue to worsen as a global epidemic. The underlying cause of CVD is atherosclerosis: most myocardial infarctions ... -
Size Matters: The Influence of Isoform Size on the Intracellular Processing of Apolipoprotein(a)
(2009-09-23)High plasma concentrations of Lipoprotein(a) (Lp(a)) have been identified as a risk factor for a variety of atherogenic disorders such as cerebrovascular disease, peripheral vascular disease, and coronary heart disease. ... -
Small Proline Rich Protein-2 Expression and Regulation in the Caco-2 model of Intestinal Epithelial Differentiation along the Crypt-Villus Axis
(2008-04-28)Small proline-rich protein-2 (SPRR2) functions as a determinant of flexibility and permeability in the mature cornified envelope of the skin. SPRR2 is strongly upregulated by the commensal flora and may mediate signaling ... -
Structural and Functional Characterization of a Novel Heterodimeric Kinesin in Candida albicans
(2012-03-01)Kinesins are molecular motors that transport intracellular cargos along microtubules (MTs) and influence the organization and dynamics of the MT cytoskeleton. Their force-generating functions arise from conformational ... -
Structural and functional characterization of E2A:KIX interactions in leukemia
(2012-09-15)The E2A proteins are transcription factors critical for B-lymphopoiesis. A chromosomal translocation involving the E2A gene promotes acute lymphoblastic leukemia (ALL) through expression of the oncoprotein E2A-PBX1. Two ... -
Structural and Functional Characterization of the Human Tribbles Homologue 2 Pseudokinase
(2016-10-27)The Tribbles Homologues are a family of three eukaryotic pseudokinases (Trb1, Trb2, Trb3) that act as allosteric inhibitors and regulatory scaffold sites in pathways governing adipogenesis, cell proliferation and insulin ... -
Structural and Functional Correlates of Exercise Ventilatory Inefficiency in Chronic Obstructive Pulmonary Disease Patients With Mild-to-Moderate Spirometric Abnormalities
(2016-08-23)Background: Individuals with chronic obstructive pulmonary disease (COPD) have higher than normal ventilatory equivalents for carbon dioxide (VE/VCO2) during exercise. There is growing evidence that emphysema on thoracic ... -
Structural and functional studies of bacterial protein tyrosine kinases
(2008-09-27)While protein tyrosine kinases (PTKs) have been extensively characterized in eukaryotes, far less is known about their emerging counterparts in prokaryotes. Studies of close to 20 homologs of bacterial protein tyrosine ... -
Structural and Functional Studies of Escherichia coli Kinases and Phosphatases
(2010-06-24)Phosphorylation/dephosphorylation is likely the most crucial chemical reaction taking place in all living organisms. It is the basis for the regulatory control of many diverse biological events triggered by extracellular ...