Browsing Biomedical and Molecular Sciences, Department of by Type "thesis"
Now showing items 1-20 of 433
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Abnormal inflammation in a rat model of spontaneous fetal loss leads to maternal coagulopathies associated with placental haemostatic alterations
(2011-08-10)Spontaneous foetal loss is the most common complication of pregnancy, affecting up to 20% of recognized pregnancies and recurring in 1-3% of cases. Abnormal maternal inflammation and systemic maternal coagulopathies are ... -
Activation of Heme Oxygenase-2 to Improve Outcome After Traumatic Brain Injury
(2014-07-02)Traumatic brain injury (TBI) is an injury of the brain most often caused by blunt force trauma to the head and typically characterized by an increase in reactive oxygen species (ROS), inflammation, and hemorrhaging. Heme ... -
Activation of the corticolimbic brain by visual food cues; Effect of menstrual cycle phase and mood
(2009-09-27)Hypothalamic control of food intake may be overridden by cortical and limbic brain regions that process reward and the hedonic aspect of food, affecting the ability to discriminate between homeostatic and hedonic feeding. ... -
Adhesion Proteins: Keeping Bacteria in Their Place
Many bacteria produce outer membrane-localized proteins that adhere them to varying biotic and abiotic substrates. Such interactions are crucial for the life-cycle of many microorganisms, promoting retention in high-nutrient ... -
The Adipocyte and Endothelial Cell-Specific Role of Peroxisome Proliferator-Activated Receptor Gamma in Breast Tumourigenesis
(2013-01-04)Peroxisome proliferator-activated receptor (PPAR)γ plays a role in tumorigenesis. Previous studies with PPARγ(+/-) mice suggest PPARγ normally suppresses dimethylbenz[a]anthracene (DMBA)-induced breast, and other, tumor ... -
Aldehyde Dehydrogenase 2 Knockout Mice as a Potential Model of Vascular Cognitive Impairment and Alzheimer's Disease
Oxidative stress causes tissue damage in several models of vascular cognitive impairment (VCI) and in age-related Alzheimer’s disease (AD). We have developed a novel oxidative stress-based mouse model of age-related cognitive ... -
Alteration in MicroRNA Expression Pattern in CD-1 Mouse Fetal Liver Cells Following In Vitro Benzoquinone Exposure
The incidence of childhood leukemias in developed countries is increasing and in utero exposure to environmental toxicants such as benzene may be primarily responsible. The mechanism behind benzene- induced hematotoxicity ... -
Altered Vasomotion Characteristics as a Method of Investigating Vascular Phenotypic Change
(2008-09-27)Vasomotion is the spontaneous oscillation of vascular tone, occurring due to synchronization of internal calcium fluctuations between multiple vascular smooth muscle cells by gap junction and electrical communication. ... -
Analysis of a bacterial serine/threonine kinase
(2007-12-05)RdoA is a bacterial protein kinase from Salmonella enterica serovar Typhimurium first noted for its regulation of dsbA expression in this organism. The crystal structure of RdoA’s homologue, YihE from Escherichia coli, ... -
Analysis of Lipoprotein(a) Catabolism
(2009-09-27)Elevated plasma concentrations of lipoprotein(a) [Lp(a)] have been identified as an independent risk factor for vascular diseases including coronary heart disease and stroke. In the current study, we have examined the ... -
Analysis of Lymphocytic Choriomeningitis Virus Antigens Presentation by Macrophages
(2010-04-13)The activation of cytotoxic T-cell (CTL) responses requires antigen presentation by professional antigen presenting cells. Macrophages (MØ) can regulate CTL responses but little is known about the role played by splenic ... -
Analysis of N-linked glycosylation of flagellin proteins in the archaeon Methanococcus maripaludis
(2007-10-01)N-linked glycosylation is a posttranslational modification involving the attachment of a carbohydrate to an asparagine (Asn) residue located within an Asn-X-Ser/Thr consensus sequence. This process is well understood in ... -
Analysis of parameters of haemostasis in pre-eclamptic, normotensive pregnant and non-pregnant women.
(2014-10-21)Pregnancy is characterized by a state of heightened coagulation, which is exacerbated in pathological conditions such as pre-eclampsia (PET). PET is further associated with abnormal maternal inflammation and increased ... -
Antifreeze Protein Engineering
This thesis describes: 1) the use of protein engineering to increase ice-binding protein (IBP) activity and thermal stability, and 2) the binding interaction and microcolony formation between an Antarctic bacterium and ... -
Antifreeze Proteins: Activity Comparisons and De Novo Design of an Ice-Binding Protein
(2010-02-01)Antifreeze proteins (AFPs) help cold-adapted organisms survive below 0 ◦C by binding to and inhibiting the growth of ice crystals. In this way, AFPs depress the freezing point of aqueous fluids below the melting point of ... -
Apoliprotein(a)-Induced Apoptosis in Vascular Endothelial Cells
(2011-06-20)Elevated plasma concentrations of lipoprotein(a) (Lp(a)) are a risk factor for a variety of atherosclerotic disorders including coronary heart disease. In the current study, the investigators report that incubation of ... -
Archaeal signal peptides and cell surface structures
(2007-10-11)Archaeal protein trafficking is a poorly understood process that is only beginning to unfold. Integral to this process are the various signal peptidases. Two types of archaeal signal peptidases are identified thus far: ... -
The Area Postrema: A Potential Site for Circadian Regulation by Prokineticin 2
(2009-08-20)Little is known regarding the neurophysiological mechanisms by which the neuropeptide prokineticin 2 (PK2) regulates circadian rhythms. Using whole-cell electrophysiology, we have investigated a potential role for regulation ... -
Assembly of the O Antigen in the Highly Pathogenic Escherichia Coli Serotype O104:H4
Escherichia coli serotype O104:H4 (ECO104) is an intestinal pathogen that causes severe bloody diarrhea and hemolytic-uremic syndrome, which can lead to kidney failure and death. Lipopolysaccharides (LPS) are important ... -
Assessing Memory in an Aldehyde Dehydrogenase 2 Knockout Model of Alzheimer's Disease
(2013-09-28)The study of Alzheimer’s Disease (AD) has been hindered by the absence of animal models of late-onset/age-related AD (also termed sporadic AD) (95% of AD cases) since current transgenic mouse models exhibit pathological ...