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Attenuation of morphine tolerance, reward, and spinal gliosis in neuropathic pain by ultra-low dose alpha2-adrenergic antagonists
Aims: To determine the effects of ULD α2-AR antagonists on: i) sensory responses in morphine tolerant and nerve injured rats, ii) chronic morphine and nerve-injury induced spinal gliosis and neuronal activation, iii) ...
The Molecular and Behavioural Effects of Glial Modulators Propentofylline and PJ34 in a Rodent Model of Neuropathic Pain
Neuronal-glial interactions play an important role in the development of neuropathic (NP) pain states. Earlier studies in our laboratory suggest a role for activated glia in morphine-induced delta opioid receptor (DOR) ...