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Investigating Organic Nitrate Tolerance and Alzheimer's Disease: Roles for Aldehyde Dehydrogenase 2 and 4-Hydroxynonenal
Organic nitrates, such as glyceryl trinitrate (GTN), have been used clinically for more than a century. However optimal nitrate therapy is hindered by the development of tolerance, which is associated with a desensitized ...
The Role of Aldehyde Dehydrogenase 2 in Nitrate Tolerance
Organic nitrates such as glyceryl trinitrate (GTN) are commonly used to treat myocardial ischemia and congestive heart failure. GTN is proposed to act as a prodrug that requires bioactivation for pharmacological activity. ...