Now showing items 1-10 of 105
NMR and Biophysical Studies of Modular Protein Structure and Function
Proteins modularity enhances the multi-functionality and versatility of proteins by providing such properties as multiple and various ligand-binding sites, increased ligand affinity through the avidity effect, and the ...
The Identification and Characterization of an Inner Acrosomal Membrane Associated Protein, IAM38, Responsible for Secondary Sperm-Zona Binding During Fertilization
During mammalian fertilization, the exposure of the inner acrosomal membrane (IAM) after acrosomal exocytosis is essential for the secondary binding between sperm and zona pellucida (ZP) of the oocyte, a prerequisite for ...
Wnt5a Interaction with Intestinal Ror2 Regulates Villin Expression
Regulation of expression of the intestinal actin-binding protein, villin, a marker of intestinal epithelial differentiation, is poorly understood. Activation of the extracellular calcium-sensing receptor (CaSR) on ...
Small Proline Rich Protein-2 Expression and Regulation in the Caco-2 model of Intestinal Epithelial Differentiation along the Crypt-Villus Axis
Small proline-rich protein-2 (SPRR2) functions as a determinant of flexibility and permeability in the mature cornified envelope of the skin. SPRR2 is strongly upregulated by the commensal flora and may mediate signaling ...
The role of dopamine-related genes in autism spectrum disorders: Evidence for specific genes and risk for ASD in families with affected males
Individuals with autism spectrum disorders (ASDs) are impaired in cognitive processes and emotional regulation, and exhibit stereotyped behaviours. Dopamine (DA) modulates executive functions, learning, memory, emotional ...
Evidence Linking the Structure and Function of the Internal Pudendal Artery to Erectile Function: Impact of Aging, Hypertension, Antihypertensive Treatments and Lifestyle Modifications
Erectile dysfunction and cardiovascular disease share etiologies, and commonly coexist. One unifying concept is that the arterial insufficiency in hypertension is also the primary basis for blunted sexual responses. The ...
Investigating the contribution of the basal ganglia in the selective gating of saccade initiation
An important function of the brain is to inhibit irrelevant behaviors. This thesis examines the role of the basal ganglia in response suppression using saccadic eye movements as a model of behavior. We measured the activity ...
Influence of Membrane-Damaging Agents and the Sigma Factor AlgU on the Induction of the MexCD-OprJ Efflux System of Pseudomonas Aeruginosa
The MexCD-OprJ multidrug efflux pump of Pseudomonas aeruginosa confers resistance to a range of antimicrobials. Although not expressed under normal laboratory conditions, exposure to the membrane-active biocides, chlorhexidine ...
The Role of Aldehyde Dehydrogenase 2 in Nitrate Tolerance
Organic nitrates such as glyceryl trinitrate (GTN) are commonly used to treat myocardial ischemia and congestive heart failure. GTN is proposed to act as a prodrug that requires bioactivation for pharmacological activity. ...