• O antigen biosynthesis in Gram-negative bacteria: Characterization of alpha1,4-glucosyltransferase WclY from Escherichia coli O117 and development of glycosyltransferase inhibitors. 

  Kocev, Alex

  Gram-negative bacteria have a polysaccharide coat (O antigen) consisting of repeating units of oligosaccharides that is assembled by glycosyltransferases. Many of these bacteria are associated with disease, and the ...

• Crosstalk Signaling Between cAMP and Calcium on the Leading Edge of Migrating Human Arterial Vascular Smooth Muscle Cells 

  Brzezinska, Paulina

  Vascular smooth muscle cells (VSMCs) are phenotypically plastic. Thus, while the VSMCs in healthy blood vessels are ‘contractile’ and control vascular tone, these cells can increase their synthetic, migratory and proliferative ...

• Integrated Biological Networks Associated with Platinum-Based Chemotherapy Response in High-Grade Serous Ovarian Cancer 

  Topouza, Danai

  Ovarian cancer is the 8th most common gynecological cancer and the 7th leading cause of cancer death in women, as it has the lowest 5-year survival rate of all common female reproductive system cancers. The first-line ...

• The Effect of In Utero Benzene Exposure on Fetal NF-KB Cell Signalling in CD-1 Mice 

  Lu, Peter

  In utero exposure to benzene, a known carcinogenic environmental toxicant, is associated with the development of childhood leukemia. We have previously demonstrated that in utero exposure to benzene in CD-1 mice can alter ...

• The developmental and functional characterization of glutathione-s-transferase omega 2 (GSTO2) within eutherian spermatozoa 

  Hamilton, Lauren

  The eutherian sperm head has three main components: the nucleus, acrosome and perinuclear theca (PT). The PT is a dense cytosolic protein layer that lies between the nucleus and acrosome and houses proteins involved in ...

• Investigating the Role of Camp-Signaling in the Regulation of Angiogenic Sprouting 

  Mackeil, Jodi

  Angiogenesis, the growth of blood vessels from pre-existing vascular structures, can contribute adaptively or mal-adaptively to a myriad of conditions, including ischemic heart disease and cancer. During angiogenic sprouting, ...

• The Circulating Factors and Tissue Mechanisms Associated With Vascular Calcification 

  Forster, Corey

• Clinical Symptoms And Biomarkers Of Bermuda Grass-Induced Allergic Rhinitis Using The Nasal Allergen Challenge Model 

  Rawls, Matt

  Bermuda grass pollen is a prevalent allergen that flourishes in subtropical climates, such as the southern United States. Bermuda grass exposure is traditionally believed to be relatively low in Ontario due to the colder ...

• The Role of Fucosylation in a Three-Dimensional Multicellular Tumor Spheroid Model of Prostate Cancer 

  Kalaydina, Nicka

  Multicellular tumor spheroids are a three-dimensional model of cancer with a variety of applications. Spheroids are the preferred preclinical model in drug screening because they recapitulate the tumor microenvironment. ...

• Connecting environmental exposures with allergic and respiratory outcomes - The ongoing study of the Kingston Allergy Birth Cohort 

  Gallant, Mallory

  Atopic diseases like allergies and asthma are mediated by several types of immune cells such as Regulatory T cells (Treg), and T helper type 1, 2, and 17 (Th1, Th2, and Th17) cells. Reductions in Treg numbers and the Th1:Th2 ...

• Granulocyte macrophage colony stimulating factor and macrophage colony stimulating factor compete to differentially regulate bone marrow-derived macrophage activation and polarization 

  Trus, Evan

  Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) and Macrophage Colony Stimulating Factor (M-CSF) are two highly regulated cytokines with a variety of roles in the immune system. One of their most impactful roles ...

• Ventricular Arrhythmia Risk Assessment with Novel Time-Frequency Analysis of Signal-Averaged Electrocardiograms 

  Chow, Ryan

  Background: Ventricular arrhythmia is a prevalent and dangerous cause of sudden cardiac death. Implantable cardioverter defibrillators (ICD) are devices that can detect and terminate ventricular arrhythmia, but current ...

• The Effect of Carbon Monoxide on Pregnancy Specific Adaptations in Mice 

  Dickson, Megan

  Preeclampsia (PE) is a multisystem disorder of pregnancy, characterized by new onset hypertension and the presence of specific organ dysfunction such as proteinuria. While the etiology remains elusive, it is believed to ...

• Investigating the impact of endothelial BMPR2 loss on the proliferative response to bone morphogenetic protein 9 in pulmonary arterial hypertension 

  Theilmann, Anne

  Objective: Pulmonary arterial hypertension (PAH) is a disease of proliferative vascular occlusion that is strongly linked to heterozygous mutations in BMPR2, the gene encoding the bone morphogenetic protein (BMP) type II ...

• Adhesion Proteins: Keeping Bacteria in Their Place 

  Vance, Tyler

  Many bacteria produce outer membrane-localized proteins that adhere them to varying biotic and abiotic substrates. Such interactions are crucial for the life-cycle of many microorganisms, promoting retention in high-nutrient ...

• Interleukin-27 Modulates Monocyte and Macrophage Toll-Like Receptor Responses to Bacterial and Viral Components 

  Odoardi, Natalya

  Interleukin (IL)-27 is a heterodimeric cytokine with pleiotropic functions across both innate and adaptive immunity. Composed of subunits IL-27p28 and EBI3, IL-27 signals via a heterodimeric receptor of gp130 and WSX-1 to ...

• Investigating the Role of Neutrophils in Endometriosis Pathophysiology 

  Symons, Lindsey

  Endometriosis is a debilitating gynecological disease characterized by the presence of endometrial-like tissue lesions outside of the uterus. Chronic inflammation is a hallmark feature of endometriosis, which has been ...

• Blockade of the Human Ether A-Go-Go-Related Gene (hERG) Potassium Channel by Fentanyl 

  Tschirhart, Jared

  Fentanyl poses a serious health concern, with abuse and death rates rising over recent years. Despite the high number of overdose deaths attributed to fentanyl, the complete molecular mechanisms of such deaths have not ...

• The Role of Recombinant Oviduct-Specific Glycoprotein (OVGP1) During Early Events of Fertilization 

  Zhao, Yuewen

  The mammalian oviductal secretory cells synthesize and secrete a major glycoprotein known as the oviduct-specific glycoprotein (OVGP1) which is in abundance around the time of fertilization. In vitro studies carried out ...

• Single Nucleotide Polymorphism of B-Type Natriuretic Peptide and Carotid Ultrasound Imaging as Biomarkers to Determine the Severity of Atherosclerosis 

  Li, Terry

  Cardiovascular disease (CVD) has been the number one cause of death in the world for several decades and will continue to worsen as a global epidemic. The underlying cause of CVD is atherosclerosis: most myocardial infarctions ...

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