Now showing items 1-5 of 5
Structural and Functional Studies of Regulatory Proteins in the Bacterial Exopolysaccharide Synthesis and Transport Pathways
Extracellular sugar polymers, or exopolysaccharides, play crucial roles in gram-negative bacteria that enable their survival and proliferation in hostile environments. As a result, the proteins involved in the synthesis, ...
Structural Basis of Antifreeze Proteins Binding to Ice
Antifreeze proteins (AFPs) are a class of proteins that adsorb to the surface of ice crystals to prevent their growth. Recent structural work has shown that the ice-binding site (IBS) of a bacterial AFP organizes surface ...
Glycemic State Regulates Brain-Derived Neurotrophic Factor Responsiveness of Neurons in the Paraventricular Nucleus of the Hypothalamus
Brain derived neurotrophic factor (BDNF) is a member of the family of neurotrophins and binds to the tropomyosin-related kinase B (TrkB) receptor. Like other neurotrophic factors, BDNF is involved in the development and ...
Functional Characterization of Human ADCK3 and ADCK4, Mitochondrial Atypical Kinases
AarF domain containing kinases 3 and 4 (ADCK3 and ADCK4, respectively) are paralogous human mitochondrial proteins, co-orthologs of the yeast protein Coq8 and bacterial protein UbiB. These proteins are required in the ...
Calcium and Phosphate Disposition in Chronic Kidney Disease
Cardiovascular disease is the leading cause of death in patients with chronic kidney disease (CKD). Vascular calcification (VC) is the most prevalent form of cardiovascular disease in this population and the attributable ...