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dc.contributor.authorIslam, Saadulen
dc.date.accessioned2016-12-12T19:29:43Z
dc.date.available2016-12-12T19:29:43Z
dc.identifier.urihttp://hdl.handle.net/1974/15282
dc.description.abstractBackground: The role of common, low to intermediate risk alleles in breast cancer need to be examined due to their relatively high prevalence. Among many cellular pathways, replication has a pivotal role in cell division and frequently targeted during carcinogenesis. Replication is governed by a host of genes involved in a number of different pathways. This study investigates the effects of replication-gene variants in relation to breast cancer and how this relationship is affected by ethnicity, menopausal status and breast tumour subtype. Methods: Data from a case-control study with 997 incident breast cancer cases and 1,050 age frequency matched controls in Vancouver, British Columbia and Kingston, Ontario were used. Unconditional logistic regression was used to calculate odds ratios between 45 replication gene variants and breast cancer risk, assuming an additive genetic model adjusted for age and centre, presented for Europeans and East Asians separately. Polytomous logistic regression was used to assess odds ratios between each SNP and four breast cancer subtypes defined by hormone receptor status among Europeans. All analyses were stratified by menopausal status. The Benjamini–Hochberg false discovery rate (FDR) was used to address multiple comparisons. Results: Among Europeans, the SNPs in FGFR2, TOX3 and 11q13 loci were associated with breast cancer after controlling for multiple comparisons. Test of heterogeneity showed the SNPs rs1045185, rs4973768, rs672888, rs1219648, rs2420946 among Europeans and rs889312 among East Asians conferred differential risk across the tumour subtypes. Conclusions: Specific SNPs in replication genes were associated with breast cancer, and the risk level differed by tumour subtype defined by ER/PR/Her2 status and ethnicity.en
dc.language.isoengen
dc.relation.ispartofseriesCanadian thesesen
dc.rightsQueen's University's Thesis/Dissertation Non-Exclusive License for Deposit to QSpace and Library and Archives Canadaen
dc.rightsProQuest PhD and Master's Theses International Dissemination Agreementen
dc.rightsIntellectual Property Guidelines at Queen's Universityen
dc.rightsCopying and Preserving Your Thesisen
dc.rightsThis publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.en
dc.subjectBreast Canceren
dc.subjectSingle Nucleotide Polymorphismen
dc.subjectReplicationen
dc.subjectTumour Subtypeen
dc.subjectHeterogeneityen
dc.titleGenetic Polymorphisms in Replication-related Genes and Risk of Breast Cancer Among European and East Asian Womenen
dc.typethesisen
dc.description.degreeM.Sc.en
dc.contributor.supervisorAronson, Kristan J.en
dc.contributor.departmentPublic Health Sciencesen
dc.embargo.termsWe do not want anyone to have access to this unpublished data.en
dc.embargo.liftdate2021-12-08T22:14:35Z
dc.degree.grantorQueen's University at Kingstonen


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