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dc.contributor.authorLi, Terry
dc.contributor.otherQueen's University (Kingston, Ont.). Theses (Queen's University (Kingston, Ont.))en
dc.date.accessioned2019-04-23T20:28:10Z
dc.date.available2019-04-23T20:28:10Z
dc.identifier.urihttp://hdl.handle.net/1974/26102
dc.description.abstractCardiovascular disease (CVD) has been the number one cause of death in the world for several decades and will continue to worsen as a global epidemic. The underlying cause of CVD is atherosclerosis: most myocardial infarctions are caused by atherosclerotic plaque build-up in the coronary arteries, also known as coronary artery disease (CAD). Even though the exact mechanism is unknown, hemodynamic disturbance is a potential precursor for atherosclerotic development. The natriuretic peptide system, especially B-type natriuretic peptide (BNP), plays an important role in hemodynamic regulation. Genetic variants, such as single nucleotide polymorphisms (SNPs), of the BNP gene affect its expression and correlate with increased circulating BNP levels. The goal of this thesis research is to determine if SNPs of the natriuretic peptide system contributes to atherosclerotic development, and if these genetic variants can help predict CVD. We recruited 513 patients from Kingston General Hospital, who were undergoing coronary angiography, the clinical standard for detecting CAD. Blood sample was collected from each patient for genetic analysis. BNP gene SNP, rs198389, was significantly associated with severe CAD in women but not in men. It suggests that the mechanism of atherosclerosis development may differ between the sexes. In the second portion of the thesis, we investigated the role of genetic mutation in atherosclerosis in the carotid arteries, major arteries in the neck. Ultrasound was used to reveal and quantify carotid plaques, which correlated with the severity of plaques in coronary arteries. BNP genetic variant, rs198389, was associated with the extend of atherosclerosis in the carotid artery. In the final part of the thesis, we evaluated major adverse cardiovascular events such as heart attack, stroke and cardiovascular death. The SNP rs198389 was found to be a significant predictor for early cardiovascular events, as well as recurrent events. In summary, this thesis demonstrates that the BNP genetic variant rs198389 may contribute to the development of atherosclerosis in different arterial beds across the body, and it has the potential to be an important tool to predict adverse cardiovascular events.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesCanadian thesesen
dc.rightsQueen's University's Thesis/Dissertation Non-Exclusive License for Deposit to QSpace and Library and Archives Canadaen
dc.rightsProQuest PhD and Master's Theses International Dissemination Agreementen
dc.rightsIntellectual Property Guidelines at Queen's Universityen
dc.rightsCopying and Preserving Your Thesisen
dc.rightsThis publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.en
dc.subjectsingle nucleotide polymorphismen_US
dc.subjectSNPen_US
dc.subjectnatriuretic peptideen_US
dc.subjectBNPen_US
dc.subjectcarotid ultrasounden_US
dc.subjectultrasound imagingen_US
dc.subjectatherosclerosisen_US
dc.subjectcoronary artery diseaseen_US
dc.subjectcardiovascular diseaseen_US
dc.titleSingle Nucleotide Polymorphism of B-Type Natriuretic Peptide and Carotid Ultrasound Imaging as Biomarkers to Determine the Severity of Atherosclerosisen_US
dc.typethesisen
dc.description.degreeDoctor of Philosophyen_US
dc.contributor.supervisorPang, Stephen
dc.contributor.supervisorJohri, Amer
dc.contributor.departmentBiomedical and Molecular Sciencesen_US
dc.embargo.termsAllow time to complete the submission of manuscripts to scientific journals for publication.en_US
dc.embargo.liftdate2024-04-23T15:52:43Z


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