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The Effect Manipulating AMPK Activity has on Ouabain-Induced Spreading Depression in Fed and Starved Locusta Migratoria.
Neurons, though highly metabolically active, have a poor capacity for nutrient storage and are sensitive to energy fluctuations. One mechanism for maintaining energetic homeostasis involves activation of the heterotrimeric ...
Using Insect Model Systems to Study Mechanisms of Spreading Depression
Spreading depression (SD) occurs as a slowly propagating wave of neural inactivity and plays an important role in both the vertebrate and invertebrate CNS. Mammalian SD is associated with human pathologies such as migraine, ...