Browsing Queen's Graduate Theses and Dissertations by Title
Now showing items 5103-5122 of 6294
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Role of STAT1 in Disease Progression and the Tumour Immune Microenvironment of High-Grade Serous Ovarian Cancer
Ovarian high-grade serous carcinomas (HGSC) are the most common and fatal histological subtype of ovarian cancer, characterised by late stage diagnosis and high mortality rates. Unfortunately, the majority of patients (> ... -
The Role of Stat3 in Adipocytic Differentiation
(2014-09-27)Cellular proliferation is often regulated in conjunction with differentiation. It is important to investigate the mechanisms underlying cellular differentiation and proliferation, because defects in their control can ... -
The role of Stat3 in cell division and apoptosis
(2009-04-27)The Signal Transducer and Activator of Transcription-3 (Stat3) is a transcription factor that is required for transformation by a number of oncogenes, while a constitutively active form of Stat3 alone is sufficient to ... -
The Role of Stress Waves and Gases in the Development of Fragmentation
(2016-01-05)There are two components to a blast which create damage in a rock or grout material: the initial stress wave, followed by the crack penetrating gases. In order to understand the development of fragmentation in grout as a ... -
Role of Stromal Cell-Derived Factor-1 in Neoangiogenesis in Endometriosis Lesions
(2011-12-22)Endometriosis affects 5-10% of women and is characterized by the growth of endometrial tissue outside of the uterus. Treatment for endometriosis primarily focuses on symptom relief, is short term with severe side effects ... -
The role of surface fossil magnetic fields in massive star evolution
Models describing the evolution of massive stars have advanced significantly due to understanding and including key physical phenomena in the calculations, such as mass loss and rotation. As stellar magnetometry has ... -
The Role of TET2 in Macrophage Differentiation and Polarization
The epigenetic regulator Tet methylcytosine dioxygenase 2 (TET2) catalyzes the conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), leading to DNA demethylation. Inactivating TET2 mutations are common ... -
Role of the Cadherin-11/Rac1/Stat3 Axis in Src-Mediated Transformation and in Adipocytic Differentiation
Stat3 (signal transducer and activator of transcription-3) is activated by phosphorylation on tyrosine-705 (Stat3-ptyr705) downstream of cytokines, growth factors, and oncogenes. Our lab has demonstrated that engagement ... -
The role of the epithelial-mesenchymal transition in aggressive tumour phenotypes
(2014-10-28)The epithelial-mesenchymal transition (EMT) is an evolutionarily conserved developmental process characterized by the loss of intercellular contacts, changes in cell polarity and increased migration and invasion. EMT has ... -
The role of the Fer protein-tyrosine kinase in HER2-positive breast cancer
(2015-07-31)Fer is a member of a distinct subclass of cytoplasmic protein-tyrosine kinases with homology to a family of adaptor proteins that regulate membrane-cytoskeletal remodeling events, including receptor endocytosis. Fer has ... -
Role of the Frontal Eye Field, Superior Colliculus, and Basal Ganglia in Flexible Saccade Behavior
A distributed network of cortical and subcortical brain regions mediates the control of voluntary behavior, but it is unclear how this complex system may flexibly shift between different behavioral events. This thesis ... -
The Role of the Frontal Eye Fields in Selecting Mixed-Strategy Saccades
(2012-03-29)In a multi‐agent environment, animals must often adopt a stochastic mixed‐strategy approach to maximize reward and minimize costs; otherwise, competitive opponents can exploit predictable choice patterns. This thesis tested ... -
The Role of the Tyrrell Sea Aquitard and Bioherms in the Hydrogeology of the James Bay Lowlands Under Dewatering Conditions
(2013-02-07)The Hudson-James Bay Lowlands (HJBL) are composed of fens and bogs frequently intersected by rivers and punctured by bioherms (ancient reef mounds) rising from bedrock aquifer. The peatlands exist partly due to minimal ... -
The role of the visual train ornament in the courtship of peafowl, Pavo cristatus
(2008-09-15)The peacock (Pavo cristatus) has long been considered the quintessential example of a sexually selected animal, and in the last two decades, peafowl have provided widely-cited evidence for female mate choice as well as the ... -
The role of theory of mind in the relation between victimization and depressive symptoms
(2015-08-26)Theory of mind (ToM) is the ability to identify others’ mental states, and use this information to explain or predict others’ behaviours. Typically developing adolescents use this ability with varying degree of efficiency ... -
The Role of Unmet Needs in Self-Harming Behaviours
(2015-07-21)Suicide and self-mutilation are widespread societal issues, making them an important area of research. The interpersonal theory of suicide (ITS) and Shneidman’s theory of psychache have each garnered substantial support ... -
The role of vitamin D signalling in the interaction between mesenchymal mammary tumour cells and macrophages
(2016-09-01)The transition of epithelial-like tumour cells to those exhibiting mesenchymal characteristics (Epithelial-to-mesenchymal Transition; EMT) is an integral process in breast cancer metastasis. EMT can be promoted by Transforming ... -
The Role of Vitamin K in Vascular Calcification in a Rat Model of Chronic Kidney Disease
(2015-01-12)Chronic kidney disease (CKD) affects approximately 3 million Canadians and these patients have a markedly increased risk of developing cardiovascular disease. CKD patients have abnormal mineral metabolism and vitamin K ... -
The role of von Willebrand factor in the pathogenesis of immunothrombosis
Pathologic immunothrombosis is the formation of arterial, venous or microvascular thrombi in response to dysregulated activation of the immune system. Inflammatory diseases such as sepsis and obesity are associated with a ... -
Roles of Arginase-1 in Neural Cells
Arginase-1 (ARG1) is an essential urea cycle (UC) enzyme that catalyzes the hydrolysis of arginine, proposed to also be involved in pre- and post-natal development and post-injury regeneration of neural cells. Genetic ...