Department of Pathology and Molecular Medicine Graduate Theses
Recent Submissions
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Prognostic Features of Non-Muscle-Invasive Bladder Cancer: Grade, Molecular Subtype and Tumour Immune Microenvironment
Intrinsic molecular subtypes with luminal or basal features have been identified in both breast and bladder cancer as promising areas for biomarker development. These intrinsic molecular subtypes may explain marked variation ... -
Performance of IHC3-Uro Immunohistochemistry-based Molecular Subtyping in Muscle-Invasive Bladder Cancer
Molecular subtyping in muscle-invasive bladder cancer (MIBC) has shown important relationships to both prognosis and chemosensitivity. However, insufficient validation and complex testing methods have prevented molecular ... -
Evaluation of basal and stimulated von Willebrand factor release from endothelial colony forming cells derived from Type 1 von Willebrand disease patients
Type 1 von Willebrand disease (VWD) is the most common bleeding disorder and is thought to be caused by a quantitative deficiency in von Willebrand factor (VWF). Endothelial cells release VWF into the circulation in an ... -
Systematic Identification of Interaction Partners of RET Receptor Isoforms
The REarranged during Transfection (RET) receptor tyrosine kinase is pivotal for normal development of human tissues, but is also an oncogene driver involved in several human cancers. Alternative splicing at the 3’ end ... -
Identification of Novel Small Molecule Inhibitors (SMI) of YAP/TAZ Oncoproteins in Breast Cancer Using HiBiT Bioluminescent Biosensors
Breast cancer (BC) is the most frequently diagnosed cancer among females, accounting for 25% of all cancer cases worldwide. Among all the subtypes of BC, triple negative breast cancer (TNBC) is considered one of the ... -
The Effects of TET2-Deficiency on Neutrophil Gene Expression and Function
Background: Clonal hematopoiesis of indeterminate potential (CHIP), a potential precursor to myelodysplastic syndrome (MDS), affects over 10% of adults over 65. Loss-of-function ten-eleven-translocation methylcytosine ... -
The Role of von Willebrand Factor in the Pathogenesis of Deep Vein Thrombosis in Acute Inflammation
Venous thromboembolism, comprised of deep vein thrombosis (DVT) and pulmonary embolism, is a thrombotic cardiovascular disease that accounts for a significant portion of the global health burden. Among its risk factors, ... -
Identification and Characterization of Novel Kinases Regulating Programmed Death Ligand-1 (PD-L1) in Immune Evasion of Triple Negative Breast Cancer Cells
The programmed death ligand-1 (PD-L1) is an immune checkpoint protein expressed on a variety of antigen-presenting cells to normalize immune system. Recently, overexpression of PD-L1 on the surface of cancer cells has been ... -
Elucidating Isoform Specific Roles of Calpain-1 and Calpain-2 in Breast Cancer
Breast cancer is the most frequently diagnosed women’s cancer in Canada. Average patient survival rates are high, but they are significantly reduced for those patients whose cancer reaches stage IV – metastatic disease. ... -
Regulation of the Glucocorticoid Receptor Promoter and Its Prognostic Value in Tamoxifen-Treated ER+ Breast Cancer
Most breast cancers are estrogen receptor positive (ER+) and therefore benefit from endocrine-based therapies such as tamoxifen which impair estrogen signaling. However, resistance is a major clinical concern and ER status ... -
Comprehensive analysis of the Ontario eligibility criteria for Hereditary Breast and Ovarian Cancer Syndrome
Germline mutations in breast and ovarian cancer are rare, with approximately 10% and 13% being hereditary in origin, respectively. In 2001, the Ontario Ministry of Health and Long Term Care (MOHLTC), in an effort to contain ... -
Evaluation of the hemostatic stress response in Type 1 von Willebrand Disease
Type 1 von Willebrand Disease (VWD) is an inherited bleeding disorder resulting from a quantitative deficiency in the procoagulant protein von Willebrand factor (VWF). Diagnosis is dependent on a reduction in VWF levels ... -
Identification of Novel Receptor Tyrosine Kinases Regulating the Hippo Pathway in Cancer Cells
Several studies have shown that the Hippo pathway plays an important role in tissue growth, organ size control, and cell death. Deregulation of the Hippo pathway contributes to loss of cell contact inhibition and continuing ... -
The role of von Willebrand factor in the pathogenesis of immunothrombosis
Pathologic immunothrombosis is the formation of arterial, venous or microvascular thrombi in response to dysregulated activation of the immune system. Inflammatory diseases such as sepsis and obesity are associated with a ... -
Evaluating the relationship between the RET receptor tyrosine kinase and TMEM127
Pheochromocytomas (PCC) are highly heritable neoplasms of the adrenal gland, carrying germline mutations in approximately 40% of cases. PCC susceptibility genes have been subdivided into two clusters: hypoxia-related genes, ... -
Impact of Androgen Deprivation Therapy on the Gastrointestinal Microbiota of Prostate Cancer Patients
Background: Prostate Cancer (PCa) is one of the leading causes of cancer in men. Androgen deprivation therapy (ADT), the standard of care for advanced PCa, has been associated with developing the metabolic syndrome. The ... -
Exploring the Genomic Binding Landscape of the Oncogenic Transcription Factor TCF3-PBX1 in Acute Lymphoblastic Leukemia
Treatment of acute lymphoblastic leukemia (ALL) has become quite effective over the last two decades. However, further progress is limited by a lack of understanding of the biological processes that drive this disease. ... -
The role of PPARg-dependent microRNA expression during breast tumour metastasis
Previous studies by Dr. Nicol showed the first direct in vivo evidence that peroxisome proliferator-activated receptor (PPAR)γ normally suppresses environmental chemical 7,12-dimethylbenz[a]anthracene (DMBA)-mediated breast ... -
Differential Contributions of RET-isoforms to Tumour Invasion
RET is a receptor tyrosine kinase (RTK) which is normally activated at the cell surface by glial cell line-derived neurotrophic factors and plays critical roles during embryogenesis. RET is expressed as two protein isoforms, ... -
Novel Methods of Factor VIII Tolerance Induction in Hemophilia A Mouse Models
The most serious complication of factor VIII (FVIII) replacement therapy in hemophilia A (HA) patients remains the development of anti-FVIII antibodies (inhibitors). At this time, there are no methods to prevent inhibitor ...
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