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Controlled Synthesis of Stimuli-Responsive Network Alginate
Stimuli-responsive hydrogels swell or contract in response to external pH, ionic strength or temperature, and are of considerable interest as pharmaceutical controlled release devices. Alginate, a linear polysaccharide ...
Modification of Alginate and Development of Polymeric Nanocarriers by Living Radical Polymerization for Controlled/Targeted Drug Delivery
Alginate-based amphiphilic graft copolymers were synthesized by single electron transfer living radical polymerization (SET-LRP), forming stable micelles during polymerization induced self-assembly (PISA). First, alginate ...
Encapsulation of Protein Microfiber Networks Supporting Pancreatic Islets
A method was developed to produce and incorporate a network of discrete, genipin-crosslinked gelatin microfibers around a pancreatic islet within a barium alginate microcapsule. This technique allows for the encapsulation ...
Alginate Microparticles Produced by Spray Drying for Oral Insulin Delivery
The aim of this study was to prepare biologically active insulin-loaded alginate microparticles by spray drying. Particles were produced from three alginate feed concentrations of 1, 1.5 and 2% w/v, with respective insulin ...
Micro/Nanoencapsulation of Proteins Within Alginate/Chitosan Matrix by Spray Drying
Currently, therapeutic proteins and peptides are delivered subcutaneously, as they are readily denatured in the acidic, protease rich environment of the stomach or gastrointestinal track and low bioavailability results ...