In these experiments, we primarily investigate the role and source of nerve growth factor (NGF) in peripheral tissues undergoing chronic inflammation. It has been previously determined that there is a significant increase ...

The dysregulation of motility typical in inflammatory bowel disease (IBD) indicates involvement of the enteric nervous system (ENS). Indeed, animal models of IBD have demonstrated that intestinal inflammation is typified ...

The primary goal of this research is to understand the response of the tyrosine receptor kinase A (trkA)-expressing cells of the myenteric plexus, and dorsal root ganglia (DRG) to augmented levels of nerve growth factor ...

Background: Vascular inflammation and immune activation play important roles in intracranial aneurysm (IA) pathology. From mycotic aneurysms it is apparent that fulminant microbial infection can drive aneurysm formation ...

Intestinal functions are predominantly controlled by the enteric nervous system (ENS), which is comprised of the inner submucosal and outer myenteric plexuses. The myenteric plexus innervates the intestinal smooth muscle ...

Increasing evidence has suggested that vagal afferent neurons can mediate gut microbiota induced effects in the brain and immune modulation during gut inflammation. However, the mechanisms behind the alteration in the ...