The gray matter of the higher brain undergoes spreading depolarization in response to ischemia, which increases metabolic demand and so promotes acute neuronal injury. The molecular mechanism linking ischemic failure of ...

Following sudden failure of the Na+/K+ATPase pump, the acute neuronal swelling and dendritic damage that occurs within minutes of stroke onset are consequences of anoxic depolarization (AD). The AD front in our protocol ...

Insufficient blood flow to the brain generates widespread neurological damage, yet not all brain regions are similarly vulnerable to ischemic injury. During stroke, failure of the Na+/K+-ATPase generates a robust anoxic ...

It has been demonstrated both clinically and experimentally that the higher brain is highly vulnerable to ischemia, while the lower brain is comparatively resilient. Discovering how lower brain neurons naturally resist ...

As a result of anoxia or abrupt change in temperature spreading depolarizations (SD) occur in the grey matter of the higher brain, promoting neuronal injury. SD in mammals and insects induces a sudden shutdown of the ...

Stroke is one of the leading causes of death and long-term disability throughout developed countries. A propagating wave of mass depolarization of neurons and glia, referred to as spreading depolarization (SD), occurs ...

The dysregulation of motility typical in inflammatory bowel disease (IBD) indicates involvement of the enteric nervous system (ENS). Indeed, animal models of IBD have demonstrated that intestinal inflammation is typified ...