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An Investigation and Review of Futility Analysis Methods in Phase III Oncology Trials.
The general objective of this thesis was to improve understandings of design, conduct and analysis of randomized controlled trials (RCTs). The specific objective was to evaluate the methodological and statistical principles ...
Improving the Quality of Patient Reported Outcomes by Minimizing Missing Data
Patient-Reported Outcomes (PROs) are often included as an endpoint in prospective studies. Clinicians use the study results to help individuals with cancer make informed decisions about treatment. Missing PRO data threaten ...