Browsing Physiology Graduate Theses (July 2007 - Sept 2016) by Publish Date
Now showing items 1-20 of 62
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Up-regulation of HO-1 attenuates left ventricular remodeling post myocardial infarction in rats
(2007-10-03)Background/Objective: Reperfusion injury is a serious consequence of blood flow reestablishment after myocardial infarction (MI) mediated by reactive oxygen species and neutrophilic cellular damage. Following MI, the left ... -
Proteomic analysis of heart failure : insights into myofibril assembly and regulation
(2008-01-09)Heart failure (HF) is a prevalent disease in society which is associated with decreased cardiac output. This thesis describes the proteomic analysis of cardiac tissue obtained from HF patients and a transgenic animal model ... -
Compartmentation of the β-adrenergic Signal by phosphodiesterases in Adult Rat Ventricular Myocytes
(2008-01-18)Previous studies have suggested that phosphodiesterase (PDE) hydrolysis of cyclic adenosine monophosphate (cAMP) is important in the generation of specific and segregated cAMP signals within cells. The purpose of this ... -
Electrophysiological Effects of Angiotensin II on Hypothalamic Paraventricular Nucleus Neurons of the Rat
(2008-01-18)The role of the hypothalamic paraventricular nucleus (PVN) in cardiovascular and neuroendocrine regulation has been well documented. Much remains unknown however about the integration of synaptic signals within this nucleus ... -
Neural Regulation in Circular Smooth Muscle of Mouse Lower Esophageal Sphincter
(2008-01-30)The lower esophageal sphincter (LES) is characterized by basal tone and appropriately timed neurogenic relaxation. The physiological mechanisms underlying these crucial LES functions remain poorly understood. The current ... -
Ca2+ influx and release in Aplysia bag cell neurons
(2008-02-08)Intracellular Ca2+ is influenced by extracellular Ca2+ influx and release from internal stores. Depending on the initial influx, a range of responses can result. To better understand the processes surrounding Ca2+ handling, ... -
Ventilatory constraints and breathlessness during exercise in the elderly, in the obese, and in those with mild airflow limitation
(2008-07-08)Breathlessness during activity is increasingly recognized as a common symptom in the elderly, in older individuals with minor airway obstruction due to tobacco smoking, and in those with obesity. The underlying mechanisms ... -
Investigating the contribution of the basal ganglia in the selective gating of saccade initiation
(2008-07-22)An important function of the brain is to inhibit irrelevant behaviors. This thesis examines the role of the basal ganglia in response suppression using saccadic eye movements as a model of behavior. We measured the activity ... -
Regulation of cation channel voltage- and Ca2+-dependence in Aplysia bag cell neurons
(2008-08-27)Ion channel regulation is key to the control of excitability and behaviour. In the bag cell neurons of Aplysia californica, a voltage- and Ca2+-dependent nonselective cation channel drives a ~30-minute afterdischarge, ... -
Glial Cell Line-Derived Neurotrophic Factor Modulates Structure and Function of Postnatal Myenteric Neurons
(2008-09-04)The enteric nervous system (ENS) continues its development after birth, with formation of ganglia and functional synapses; plasticity is also demonstrated in significant axon growth that occurs after experimental colitis ... -
Mechanisms inhibiting sympathetic neurotransmitter release during gastrointestinal inflammation
(2008-09-04)Inflammatory bowel disease (IBD) alters neuronal regulation of the gastrointestinal (GI) tract. The superior mesenteric ganglia (SMG) contain sympathetic neurons that modulate GI functions such, as motility and blood flow. ... -
Jaw Movement During Sleep
(2008-09-04)Objective: We aim to improve our understanding of sleep physiology by describing the changes in mandibular position during sleep in normal subjects. Methods: We developed a novel method for mapping mandibular position ... -
The role of dopamine-related genes in autism spectrum disorders: Evidence for specific genes and risk for ASD in families with affected males
(2009-03-25)Individuals with autism spectrum disorders (ASDs) are impaired in cognitive processes and emotional regulation, and exhibit stereotyped behaviours. Dopamine (DA) modulates executive functions, learning, memory, emotional ... -
Modulation of Cardiac Myocyte Function by Reactive Oxygen Species
(2009-04-01)Previous investigations have demonstrated that reactive oxygen species such as hydrogen peroxide (H2O2) have the ability to alter electrophysiological and mechanical properties of rat ventricular cardiac myocytes. However, ... -
Mechanisms of Heme-Oxygenase-1 Cytoprotection for Gene and Cell Based Therapies against Cardiovascular Disease
(2009-04-23)Establishing the cellular and molecular basis for cardiovascular disease and the application of tools to manipulate the cardiovascular system genetically provide potential for new forms of treatment against cardiovascular ... -
Reciprocal Regulation of E-Cadherin and SHP2 by the Extracellular CA2+-Sensing Receptor in Colonic Epithelial Adenocarcinoma Cells
(2009-06-10)Colon cancer is characterized by the progressive loss of E-cadherin, a Ca2+-dependent adherens junction component and epithelial marker. Furthermore, inhibition of the phosphatase SHP2, essential in the cell survival ... -
The Role of Phosphodiesterases in Cyclic Nucleotide Compartmentation Across Different Pathways in the Adult Rat Ventricular Myocyte
(2009-07-16)In cardiac myocytes, multiple receptor mediated signalling pathways converge on cyclic nucleotide production. These second messengers act to achieve changes in cellular function. Despite this, each signalling molecule ... -
Wnt5a Interaction with Intestinal Ror2 Regulates Villin Expression
(2009-07-16)Regulation of expression of the intestinal actin-binding protein, villin, a marker of intestinal epithelial differentiation, is poorly understood. Activation of the extracellular calcium-sensing receptor (CaSR) on ... -
The Area Postrema: A Potential Site for Circadian Regulation by Prokineticin 2
(2009-08-20)Little is known regarding the neurophysiological mechanisms by which the neuropeptide prokineticin 2 (PK2) regulates circadian rhythms. Using whole-cell electrophysiology, we have investigated a potential role for regulation ... -
Interleukin-17 modulates Ca2+ currents and neurite outgrowth in sympathetic neurons
(2009-09-03)The gastrointestinal (GI) tract is subject to regulation by several neuronal networks, one of which is the sympathetic nervous system (SNS). Inflammatory bowel diseases (IBD), most importantly Crohn’s disease and ulcerative ...