Now showing items 1-5 of 5
A study of mechanisms underlying inflammation-induced abnormal nociceptive signaling from the colon in models of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD)
Abdominal pain is a common symptom of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Although the extent differs, visceral inflammation is thought to play a significant role in nociception in these ...
Electrophysiological Comparison of NaV1.5 Expressed in HEK293 Cells to Native NaV Currents in Cardiac Myocytes
Contraction of cardiac muscle is a highly regulated event that relies on a delicate balance of ions entering and leaving the cell through ion channels. In particular, voltage gated sodium channels are responsible for the ...
Reverse Atrial Electrical Remodeling Induced by Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea
Background: Obstructive sleep apnea (OSA) has been associated with atrial enlargement in response to high arterial and pulmonary pressures and increased sympathetic tone. Continuous positive airway pressure (CPAP) is the ...
A role for interleukin-17a as a mediator of sympathetic neuroanatomical remodelling during experimental colitis.
Sympathetic catecholamines and co-transmitters released within the gastrointestinal (GI) tract provide dynamic regulation of gut motility, fluid secretion, blood flow and immune cell function. Pathological GI inflammation ...
Evidence for Involvement of the Cysteinyl Leukotriene Type 2 Receptor (CysLT2R) in the Regulation of Food Intake and Body Weight and Possible Role for Vagal Afferents
The field of food intake and satiety has received increasing interest from the research community in recent years. The mechanisms and factors that regulate satiety gains their importance from the crucial role they play in ...