Now showing items 1-6 of 6
Exercise Limitation in Mild COPD: the Role of Respiratory Mechanical Factors
The majority of patients with chronic obstructive pulmonary disease (COPD) have milder airway obstruction and are not diagnosed in a timely fashion. Nevertheless, these patients are largely under-studied; this, despite new ...
Murine Phenotype Analyses and the Role of TRPV1 in Hypoxia
The environment in which animals are maintained is a factor that has the potential to alter the physiologic phenotype. We addressed the hypothesis that the standard animal care (SAC) environment cause significant deviations ...
A Study of Pro- and Anti-Nociceptive Factors In A Model of Colitis-Associated Visceral Pain
Chronic abdominal pain is a major cause of patient morbidity in inflammatory bowel diseases (IBD). A balance of pro- and anti-nociceptive factors regulating colonic dorsal root ganglion (DRG) neurons, which synapse onto ...
The Subfornical Organ and Area Postrema Mediate the Central Effects of Circulating Leptin
Leptin is an adipokine that acts centrally to regulate feeding behaviour, energy expenditure and autonomic function via activation of its receptor (ObRb) in nuclei in the central nervous system (CNS). This thesis investigates ...
Increased calcium intake regulates colonic CaSR expression and inhibits induced colitis and Wnt/β-catenin signaling
One of the major complications in patients with long standing inflammatory bowel disease (IBD) is colitis-associated colon cancer. The signaling pathways that promote the transformation of colitis to colorectal cancer (CRC) ...
Purinergic Component Involved in Long Vasodilatory Reflex in the Guinea Pig Small Intestine
Submucosal arterioles in the small intestine are the main point of control for gastrointestinal (GI) circulation as they are the final resistance vessels feeding the highly perfused mucosal layer. Ischemia can lead to ...