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An In Vitro Murine Model to Study Intestinal Mesenteric Afferent Activity in Response to Luminal Fatty Acid Stimuli
Obesity is pandemic. Pharmacological treatment development depends on modeling the regulation of feeding, particularly by free fatty acids (FFA). Most models have been employed in the rat in vivo, and show FFA-stimulated ...
The Effect of Exercise Test Modality on Dyspnea Perception in Obese Patients with COPD
Background: Obesity is becoming increasingly prevalent in patients with chronic obstructive pulmonary disease (COPD) but the physiological and clinical consequences of their combination remain poorly understood. In ...
The Subfornical Organ and Area Postrema Mediate the Central Effects of Circulating Leptin
Leptin is an adipokine that acts centrally to regulate feeding behaviour, energy expenditure and autonomic function via activation of its receptor (ObRb) in nuclei in the central nervous system (CNS). This thesis investigates ...