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Cardiac hypertrophy and expression of the natriuretic peptide system in genetic models of heme oxygenase-1
Objective: Heme oxygenase-1 (HO-1) has been well established as a cytoprotective molecule, and has been shown to exert cardioprotective effects in both hypertension and cardiac hypertrophy. However, the precise mechanism ...
Developmental Origins of Cardiovascular Disease: Atrial Natriuretic Peptide Gene Disrupted Mice as a Model of Gestational Hypertension
Introduction: Developmental origins of disease refers to the theory that adverse maternal environments influence fetal development and the risk of cardiovascular disease (CVD) in adulthood. To test the hypothesis that ...