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The Effect of Hypoxia Inducible Factor-1 on the Expression of the Coinhibitory Ligands B7-H3 and B7-H1 in Cancer: Relevance to Cancer Immune Escape
The interactions between tumour cells and cells of the immune system are important in the natural evolution of cancer, and the acquired immune system plays an integral role in cancer immune escape. B7-H3 and B7-H1 ligands ...
Role of Nitric Oxide-Signalling in Hypoxia-Induced Immune Escape in Cancer
A key step in malignant progression is the acquired ability of tumour cells to escape immune-mediated lysis. A potential mechanism by which tumour cells avoid immune destruction involves the shedding of MHC Class I ...
The multifactorial nature of hypoxia-induced drug resistance in cancer: involvement of hypoxia-inducible factor 1
The development of intratumoral hypoxia is associated with resistance to therapy in many forms of human cancer, and pre-exposure of tumor cells to hypoxia confers multidrug resistance. Research over the last several years ...